A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).本文描述一種雙重釋放經口給藥系統/劑型，其包含即刻釋放組分/組合物及延遲釋放組分/組合物。即刻釋放組分/組合物及延遲釋放組分/組合物各自包含多西拉敏(doxylamine)、其類似物、其衍生物、其前藥、其代謝物及/或其鹽中之一或多者，及吡哆醇、其鹽、其代謝物及/或該代謝物之鹽中之一或多者。該雙重釋放經口給藥系統/劑型相對於現行Diclectin®調配物展現改良之藥物動力學概況，且適用於例如減輕噁心及嘔吐症狀，例如在妊娠期噁心及嘔吐(NVP)之情況下。
