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HYDRATED N-FULLERENE AMINO ACIDS, METHOD FOR PRODUCING THE LATTER, AND PHARMACEUTICAL COMPOSITIONS ON THE BASIS THEREOF
专利权人:
发明人:
申请号:
HK14104624.0
公开号:
HK1191321A
申请日:
2014.05.19
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
The invention relates to the pharmaceutical industry and to medicine, specifically to novel hydrated amino-acid derivatives of fullerene С60 of general formula C60(H)3{NH(CH2)nCOOH}3⋅xH2O, where С60 - fullerene, n = 5, 6, 7, х = 8 - 10, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions on the basis thereof. Hydrated N-fullerene amino acids are formed in the interaction of fullerene with 15 times the molar excess of anhydrous potassium salts of amino acids in a medium of organic aromatic solvent with slow addition to the resultant suspension of an interphase catalyst and with mixing and heating to a temperature not exceeding 60 °С until the solution is completely decolorized and a solid residue formed, after which the latter is separated out, and then 0.8 M of aqueous solutions of potassium salts of fullerene amino-acid derivatives is treated with a solution of organic or mineral acids, followed by centrifugation, rinsing and drying of the residue. A pharmaceutical composition which exhibits activity against the herpes virus, flu viruses of various origin and HIV, and also anti-tumour and anti-psoriatic activity, comprising, as active substance, an effective quantity of hydrated N-fullerene amino acids.Linvention se rapporte au domaine de lindustrie pharmaceutique et de la médecine, et concerne notamment de nouveaux dérivés dacides aminés hydratés de fullerène С60 correspondant à la formule générale C60(H)3{NH(CH2)nCOOH}3⋅xH2O, où С60 représente un fullerène, n = 5, 6, 7, х = 8 - 10. Linvention concerne également un procédé de production de ces derniers, et la préparation de compositions pharmaceutiques les comprenant. Ces N-fullerène-acides aminés hydratés sont obtenus par linteraction dun fullerène avec un surplus en moles 15 fois supérieur de sels de potassium déshydratés dacides aminés dans un solvant organique aromatique et en ajoutant lentement un catalyseur interphase à la suspension ainsi obtenue tout en
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