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HLA-A*1101-omejen WT1 peptid in farmacevtski sestavek, ki ga vsebuje
专利权人:
INC.;INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY
发明人:
SUGIYAMA HARUO,Sugiyama Haruo
申请号:
SI200731565
公开号:
SI2341142T1
申请日:
2007.12.14
申请国别(地区):
SI
年份:
2015
代理人:
摘要:
The present invention relates to an HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind to an HLA-A*1101 molecule, and has an ability to induce a CTL. The present invention also relates to a peptide dimer having an ability to bind to an HLA-A*1101 molecule and having an ability to induce a CTL, in which two peptide monomers each comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein and comprising at least one cysteine residue are bound to each other through a disulfide bond. Furthermore, the present invention relates to a polynucleotide encoding the peptide, a pharmaceutical composition for the treatment and/or prevention of a cancer comprising the same and the like.
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