BROUILLETTE, Wayne,MUCCIO, Donald,ATIGADDA, Venkatram,RUPPERT, John,LOBO RUPPERT, Susan
申请号：
ES13831096
公开号：
ES2670499T3
申请日:
2013.07.01
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound having the chemical formula shown as formula III: ** Formula ** in which, R3 is one or more groups comprising, independently, H, F, difluoro, CF3, a C1-C15 straight or branched chain alkyl group , a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group, a substituted or unsubstituted cycloalkyl group； R6 and R7 are, independently, H, CF3, a C1-C15 straight or branched chain alkyl group, or a substituted or unsubstituted cycloalkyl group； R9 is one or more groups comprising, independently, H, CF3, a C1-C15 straight or branched chain alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group, or a substituted or cycloalkyl group or not substituted； R11 is H, or a C1-C15 straight or branched chain alkyl group； n is from 0 to 3； wherein one or more carbons in the fused ring structure may optionally be replaced by a heteroatom； or a pharmaceutically acceptable salt or enantiomeric, diastereomeric or geometric isomer thereof, for use in the treatment, prevention or improvement of a non-neoplastic cutaneous condition selected from acne vulgaris, psoriasis, rosacea, actinic keratosis, seborrheic dermatitis, actinic lentigos , photoinduced skin damage, chemotherapy-induced skin damage, keratosis, xerosis, ichthyosis, lichen, keratoderma, folliculitis, vitiligo and melasma.Compuesto que tiene la fórmula química mostrada como fórmula III:**Fórmula** en la que, R3 es uno o más grupos que comprenden, independientemente, H, F, difluoro, CF3, un grupo alquilo de cadena lineal o ramificada C1-C15, un grupo arilo sustituido o no sustituido, o un grupo aralquilo sustituido o no sustituido, un grupo cicloalquilo sustituido o no sustituido； R6 y R7 son, independientemente, H, CF3, un grupo alquilo de cadena lineal o ramificada C1-C15, o un grupo cicloalquilo sustituido o no sustituido； R9 es uno o más grupos que comprenden, independientemente, H, CF3, un grupo alquilo de cadena lineal o ramificada
