Ernest M. Wright,Jorge R. Barrio,Bruce A. Hirayama,Vladimir Kepe
申请号：
US11920904
公开号：
US08845999B2
申请日:
2006.05.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
