REMARCHUCK, TRAVIS,HALE, CHRISTOPHER,DE VICENTE FIDALGO, JAVIER,SWEENEY, ZACHARY K.,OSIPOV, MAKSIM,LEXA, KATRINA W.,FOX, BRIAN,FENG, JIANWEN A.,ESTRADA, ANTHONY A.,CRAIG II, ROBERT A.
申请号：
ARP180102270
公开号：
AR112469A1
申请日:
2018.08.09
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. This claim generally refers to eucarib initiation factor modulator, or salt, stereoisomer, stereoisomer mixture or stereoisomer mixture acceptable on drugs, and similarly claim 1: preparation and use method of formula compound (1) or salt acceptable on drugs, A similar isotopic concentrate, a stereoisomer, a stereoisomer mixture, or a stereoisomer Prof, in which case L is an optional ISO tar, replaced by 1-6 r830404, or L is an optional ISO cyclohexane, or an optional ISO cyclohexane,When l is replaced by isomerization and connected to cyclopentyl compound by nitrogen ring atom, a carbon atom near the connection point is not replaced by = or = s； X is 1 or 2； Z is 0 or 1, if Z is 0 and X1 is or, R3 is not asphalt； X1 is or No. 8313 or link； R1 is hydrogen, No. c8332131 83218c833222；Alquenilo C83228331-83218383222；1. C 83228331218322 asphalt；E. cyclohexane c8332383318321； 8320o or isocyclohexane, each non hydrogen, can be selected from one or more halides, oxo, acetylene, ammonia, hydroxyl or c8332183318321；； 832222 or R1 and r830909 are combined to form a heterocycle； R2 is hydrogen, acquilo c8332183318321832183228383838321；；Alquenilo C83228331-83218383222；1. C 83228331218322 asphalt；Alcoxi C832188331S 8321；；832222；cycloquilo C83323218331；8320；Cycloalcoxi C83232383318321；（8320）；Isopropene, isopropene or isopropene, each of which is not hydrogen, can be replaced by one or more R1,1. If l is a heterosexual, R2 is cycoalquilo c8332383318321； 8320；1. Isocyclohexane, isocyclohexane or isocyclohexane, each of which can be replaced by one or more R1；R3 º is hydrogen, one is c833218331218322, the other is c8332222；Alquenilo C83228331-83218383222；1. C 83228331218322 asphalt；cycloquilo C83323218331；8320；1. One or more R1 can be selected to replace each non hydrogen；Each r83088 and r83099 are independent hydrogen, i.e. c832183318321； 832222；A. alquenilo c83322831cf2183222 or acquinio c833228318321；Each of them, except hydrogen, can be replaced by one or more halides, oxo, a
