BAUER, Jacques,SALVAGNI, Marco,VIGROUX, Jean-Pierre,CHALVET, Laetitia,CHIAVAROLI, Carlo
申请号：
ES08731429
公开号：
ES2664990T3
申请日:
2008.03.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An extract comprising bacterial lysate product of all bacterial strains of Escherichia coli chosen from NCTC: 8603, 8621, 8622, 8623, 9026, 9111, 9119, 9707, 9708, I: 081, 082, 083, 084, 085, 086 , 087, 088 and 089, which preserves and / or retains lipopolysaccharide components, obtainable by lysing the bacterial strains at an initial pH greater than 12, wherein the extract comprises at least 0.3 mg / mL saccharides, less than 100 μg / ml of nucleic acids, between 1.5 and 2.5 mg / mL of free amino acids in glutamic acid equivalents (147.1 g / mol) chosen from aspartic acid, glutamic acid, serine, histidine, alanine, arginine, tyrosine, methionine, phenylalanine and lysine that is racemized by at least 10%, and where the extract does not represent a risk of prion diseases.Un extracto que comprende producto lisado bacteriano de todas las cepas bacterianas de Escherichia coli elegidas entre NCTC: 8603, 8621, 8622, 8623, 9026, 9111, 9119, 9707, 9708, I: 081, 082, 083, 084, 085, 086, 087, 088 y 089, que conserva y/o retiene componentes lipopolisacáridos, obtenible lisando las cepas bacterianas a un pH inicial mayor de 12, en donde el extracto comprende al menos 0,3 mg/mL de sacáridos, menos de 100 μg/ml de ácidos nucleicos, entre 1,5 y 2,5 mg/mL de aminoácidos libres en equivalentes de ácido glutámico (147,1 g/mol) elegidos entre ácido aspártico, ácido glutámico, serina, histidina, alanina, arginina, tirosina, metionina, fenilalanina y lisina que está racemizado en al menos 10%, y en donde el extracto no representa un riesgo de enfermedades priónicas.
