The compound represented by the following general formula (I) has an inhibitory activity on PAI-1 productionwherein R1 represents, for example, a hydrogen atom, or a 4-(morpholinyl)carlaonyl group, ring D represents, for example, a benzene ring or a benzene ring having substituent(s), and phenyl group E has substituent(s) such as a halogen atom, a halogenated alkyl group, an alkyl group, a halogenated alkoxy group, or an alkoxy group.
