控制組裝之多肽的製造方法

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专利权人:

发明人:

IGAWA, TOMOYUKI,井川智之,井川智之,TSUNODA, HIROYUKI,角田浩行,角田浩行

申请号：

TW095111601

公开号：

TWI544076B

申请日:

2006.03.31

申请国别(地区):

TW

年份:

2016

代理人:

摘要：

In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitablyapplied to the preparation of bispecific antibodies.發現藉由將形成多肽間組裝時之界面的胺基酸殘基改變為帶同種電荷之胺基酸,可抑制該組裝。依照本發明,可有效率地形成異分子。本發明例如可適用於製作雙專一性抗體時。

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/