tetravalent dengue vaccine containing a trivial deletion of 30 nucleotides in the utr-31 'of dengue types 1,2,3, and 4, or chimeric dengue antigenic viruses 1,2,3 and 4
THE GOVERNMENT OF THE UNITED OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE HEALTH AND HUMAN SERVICES
发明人:
BARRY FALGOUT,JOSEPH BLANEY,KATHRYN HANLEY,LEWIS MARKOFF,STEPHEN S. WHITEHEAD
申请号：
BR0309631
公开号：
BRPI0309631A2
申请日:
2003.04.25
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
A rDEN3/4”30(ME), rDEN2/4”30(ME) or rDEN1/4”30(ME) recombinant chimeric dengue virus containing a 30 nucleotide deletion (”30) in a section of the 3' untranslated region of dengue type 4 genome, where said 30 nucleotide deletion corresponds to the TL2 stem-loop structure.
