PLC &beta；1 MUTANT ANIMAL MODEL FOR TESTING MATERNAL BEHAVIOR OR PATERNAL ATTENTIVENESS, AND SCREENING METHOD FOR AGENT FOR TREATING OR PREVENTING THE DISORDER OF MATERNAL BEHAVIOR OR PATERNAL ATTENTIVENESS USING SAID ANIMAL MODEL
한국과학기술연구원;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
KOH, HAE YOUNG,고혜영,KIM, HAE JIN,김혜진,SHIN, HEE SUP,신희섭,KOH, HAE YOUNGKR,KIM, HAE JINKR,SHIN, HEE SUPKR
申请号：
KR1020140140015
公开号：
KR1020160044916A
申请日:
2014.10.16
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to an animal model system enabling the investigation of paternal attentiveness of a male mouse, by using, as a mate, a female mouse from which phospholipase C&beta；1 gene is knocked out. More specifically, the present invention relates to a mating system enabling the investigation, in various male mice, on a response associated with an increase in compensational paternal attentiveness induced by maternal attentiveness disorder of the knock-out female mice. According to the genetic animal model of the present invention, it is possible to provide a &Prime；bad mother&Prime； (or a neglecting mother) environment required for the biological investigation on paternal attentiveness in non-biparental species, without artificial manipulation such as chemical treatment or isolation.본 발명은 포스포리파제Cβ1 (Phospholipase Cβ1) 유전자가 녹-아웃(knock-out)된 암컷 생쥐를 배우자로 이용하여, 수컷 생쥐의 부성행동 (paternal attentiveness)을 검증할 수 있는 동물모델 체계로서, 구체적으로 녹-아웃(knock-out) 암컷생쥐의 모성행동 장애에 의해 유도되는 보상적(compensational) 부성행동 증가 반응을 다양한 수컷 생쥐에서 검증할 수 있도록 하는 교접 체계이다. 따라서 본 발명의 유전적 동물모델은 비양친성 종(non-biparental species)에서 부성행동 (paternal attentiveness)의 생물학을 연구하는 데에 필요한 “나쁜 엄마”(bad mother, neglecting mother) 환경을 인위적 조작(약물 처리, 격리 등) 없이 제공할 수 있다.
