LEE, CAMERON CHUCK,MUNN - HALL, EDWARD CHARLES,FORSTER, CORNELIA JUTTA,FAZAL, TANZINA,APRIL, MYRIAM,ADAMS, CHRISTOPHER M.
申请号：
ARP180101000
公开号：
AR111481A1
申请日:
2018.04.19
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
2. A drug delivery system for the management of biological active agents (including primary or secondary amino groups or nitrogen atoms in the ring), the drugs of which can accept salts, related drug reagents and drug ingredients This includes systems for the provision of drugs and the use of drug delivery systems as therapeutic agents for sustained release. 1. Claim 1: an acceptable delivery system for a medicament or medicament salt including D-R type, represented by formula (1)；D is a bioactive part, including at least one primary or secondary amino group or one nitrogen atom, or one cyclobenzidine； R is a suitable can, which can release the bioactive Part D； the dotted line indicates the combination of primary amino group and secondary amino group. O nitrogen atom in azaneteriario ring； R1 is hydrogen or c83231 tar；R¹ᵃ is hydrogen or C₁₋₄ alkyl,Or crr74191,taken in combination they form a C₃₋₆-1,1-diyl cycloalkyl； R² is independently selected at each occurrence from C₁₋₄ alkyl or oxo, or two R² groups taken in combination with the carbon atoms to which they are attached form a condensed C₃₋₆ cycloalkyl or C₃₋₆-1 cycloalkyl spiro group , 1-diyl； a is 0, 1, 2, 3 or 4； R³ is hydrogen or C₁₋₄ alkyl；R³ᵃ is hydrogen, C₁₋₄ alkyl,or CR³R³ᵃ,A cyclopentadiene-c833238331-832626-1, 1-diilo, C (o) r8308, was synthesized；C (O) ORC (O) NHRC (o) No. 8309； r8310,SiR R Ror CR¹²R¹²ᵃOR¹³；R¹² is hydrogen or C₁₋₄ alkyl；R¹²ᵃ is hydrogen or C₁₋₄ alkyl,o CR R tomados en combinaci n forman un cicloalquilo C -1 1-diilo R es alquilo COr R1 and R3,taken in combination with C (R¹²ᵃ) and O form a cyclic ether of 5, 6, or 7 members； R⁴ is C₁₋₈ alkyl or C₃₋₇ cycloalkyl,wherein the cycloalkyl is optionally substituted by 0, 1, or 2 independently selected C₁₋₄ alkyl groups and wherein the alkyl is optionally substituted by C₁₋₄ alkoxy；R⁵ and R⁶ are each independently selected from C₁₋₄ alkyl and C₃₋₆ cycloalkyl；R⁷ is C₁₋₈ alkyl,C₃₋₇ cycloalkyl,C₁₋₈ alkoxy,C₃₋₇ cycloalkyloxy,heterocycloalkyloxy, o
