SIMON TEANBY HODGSON,DAVID MICHAEL EVANS,HANNAH JOY EDWARDS,REBECCA LOUISE DAVIE
申请号：
ARP150103900
公开号：
AR102850A1
申请日:
2015.11.26
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Compounds, including the components of these compounds； use of these compounds in treatment (e.g., treatment or prevention of diseases or conditions related to the activity of powdery limestone)；And methods of treating patients with these compounds. 1. Requirement 1: a compound (1) with formula characteristics,B is phenyl substituted by 1-4 substitutes selected from tar；Alcoxi, oh, halo, CN, alien, coor831222,NHCOR⁸,CONR⁸R⁹,OCF83223,And cf83223；O b is selected from benzotiofenil, benzofuranilo, benzomorpholinio and an aperiodic ring composed of 5 to 6 members, which contains one or two heteroatoms selected from n to s； in aperiodic ring, 5 to 6 members can be aromatic or non aromatic； in the ring diphenyl benzoate, namely benzofuran, namely benzodiazepine Or 1 to 3 alternatives selected from asphalt to replace 5 to 6 members of the aperiodic ring；alcoxi OH oxo halo CN heteroarilo COORNHCOR⁸,CONR⁸R⁹,Ocf8323 and cf8323；W is C and X, y and Z are selected independently from C, N, O and s, so the ring contained in W, x, y and Z is a peculiar smell cycle composed of five members； r83099 and r8310e are absent independently or selected from h, tar, cyclopentadiene, alcoxi, halo, oh, arilo and heterogeneity respectively. Pyrethroid is composed of N, pyrethroid by N, pyrethroid by N, morphine by N, pyrethroid by N, N, nr831222； r8313；CN, COOR⁸,CONR⁸R⁹,-No. 831222； No. cor8313 and No. cf8323；a. There is at least one r83099a and r8310h, instead of H； r8311es h； a is selected from arilo and heterosexual； arilo is replaced by 1, 2 or 3 substitutes independently selected from asphalt, alcoxi, methylenedioxy, ethyldioxy, oh, halo, CN, heterosexual - (ch832222) 832083331-o-straight white, arilo 749595；-O-arylᵇ,- (CH) -arilo- (CH₂) ₁₋₃-heteroaryl, -COOR¹⁰,-CONR¹⁰R¹¹,- (CH) -NR ROcf8323 and cf8323；Alternative 1, 2 or 3 from tar, alcoxi, oh, ocf8323,halo CN arilo - (CH) -arilo - (CH) -NR RAlien 7495-COOR¹⁰,-Conr1 83040； R1 and cf832323；R⁸ and R⁹ are independently selected from H and
