您的位置: 首页 > 农业专利 > 详情页

Pyrimidine PDE10 inhibitors
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
ARP120103086
公开号:
AR087628A1
申请日:
2012.08.22
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. This list refers to pyridine compounds used as therapeutic agents for central nervous system disorders related to phosphoric acid 10. This report also deals with the use of these compounds in the treatment of neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, as well as diseases related to low physical fitness or matrix necrosis in females. 1. Characteristic 1: a compound of formula (1), wherein: A is selected from a group consisting of (1) pyridine (2) quinoolinilo, (3) naftiridinil, (4) tiazollo, (5) piridizilo,(V I) oxazolilo, y (V II) pirazolilo, (V III) dihydropirolopiazolilo, (I x) dihydrocycloopentapiridinil, (x) imidazopiridininilo y (XI) pirazopirimidinilo; B. selected as: (I) tiazolilo, (II) pirazolilo, (III) tiadiazolilo, (I V) isoxazolilo, (V) isotiazolilo, (VI) piridilo y (VII) pirimidinilo; 9174l;R¹ᵇ and R¹ᶜ are independently selected from the group consisting of: (i) hydrogen, (ii) halogen, (iii) hydroxyl, (iv) - (C = O) ₘ-Oₙ-C₁₋₆-alkyl,In case m is 0 or 1, n is 0 or 1 (if M is 0 or 0, there is a link), in this case, asphalt is not replaced or replaced with one or more alternatives selected in R3 1,(V) - (C 3DO) -O -cicloalquilo CWhere cyclopentanediol is not replaced or replaced by one or more alternatives selected in R3,(Vi) - (C 3DO) -alquenilo COne or more alternatives selected between R3 are not used to replace or replace aldicarb,(VII) - (C = O) 8344; - asphalt c832283331;Asphalt is not replaced or replaced by one or more substitutes selected from R3,(VIII) - (C = O) 8344; - phenyl o - (C = O) 8344; - O 8345; - naftillo, in which phenyl or northwest non-n-propylformic acid is not replaced by one or more alternatives selected from R3,(IX) - (C = O) 8344; - O 8345; - heterogeneous, in which one or more alternatives selected from R1 cubic meters are not replaced or replaced,(X) - (C 3DO) -NR R(Xi) -S (O) -NR R(Xii) -S (O) q-RQ is 0, 1 or 2, R1 is selected from the definitions of R1 83044 and R1,(xii
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充