CHEN, MING JU,陈明汝,陳明汝,HONG, WEI SHENG,洪伟盛,洪偉盛,CHEN, YEN PO,陈彦伯,陳彥伯,CHEN, HSI CHIA,陈希嘉,陳希嘉
申请号：
TW100103591
公开号：
TW201231057A
申请日:
2011.01.31
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention provides Lactobacillus kefiranofaciens M1 and Lactobacillus kefiri M2 isolated form kefir grain, which are effective in alleviating the secretion of pro-inflammatory, T helper cell type II (Th2) and T helper cell type 17 (Th17) cytokines, increasing regulatory T cell (Treg) population in splenocytes and inhibiting the OVA-specific IgE. The Lactobacillus kefiranofaciens M1 and Lactobacillus kefiri M2 of the present invention exhibit anti-allergic and anti-intestinal-inflammatory effects, and thus can be used for anti-allergic drugs, allergy improved-healthy/functional food or food additives.本發明提供自克弗爾粒中分離之乳酸桿菌M1(Lactobacillus kefiranofaciens M1)及乳酸桿菌M2(Lactobacillus kefiri M2),具有減緩前發炎反應(pro-inflammatory)細胞激素(cytokine)、T輔助細胞第二型(T helper cell type II,Th2)細胞激素及T輔助細胞第17型(T helper cell type 17,Th17)細胞激素分泌之功效,且能提升脾臟調節型T細胞(regulatory T cell,Treg),降低卵白蛋白(ovalbumin,OVA)特異性免疫球蛋白(immunoglobulin,Ig)E,其具有抗過敏及治療腸道發炎之機能性,可用於製作抗過敏藥物、改善過敏症狀之健康食品或保健食品,或作為食品添加成份。
