PROBLEM TO BE SOLVED: To provide an external preparation which can retain an agent, for a long time, at an infected site and a ringworm fungus living region in the vicinity thereof upon treatment of nail ringworm.SOLUTION: The external preparation for treating ringworm is composed of a water-containing gel base material dispersedly holding endoplasmic reticulums obtained by carrying constituents effective for ringworm fungus and further blended with an agent promoting skin permeation. The particle diameter of the endoplasmic reticulums is controlled so as to pass through the pores of a nail or a skin and the pores of a stratum corneum and so as not to pass through the gaps of capillary endothelial cells, further, the group of the endoplasmic reticulums is made easy to be introduced into a nail underfloor region and/or a subdermal region with a skin permeation promoter, and further, the active constituents can be retained in the region at high concentration.COPYRIGHT: (C)2012,JPO&INPIT【課題】 爪白癬の治療に際して感染部位及びその近傍の白癬菌生息領域により長く薬剤を滞留させることが可能な外用剤を提供する。【解決手段】白癬菌に有効な成分を担持してなる小胞体を分散保持すると共に皮膚透過を促進する薬剤を配合した含水ゲル基剤からなる白癬治療用外用剤であって、小胞体を、爪もしくは皮膚の細孔及び角質層細孔を通過し得るが毛細血管内皮細胞間隙を通過し得ない粒径に調節すると共に、皮膚透過促進剤により小胞体群を爪床下領域及び/又は皮下領域に導入し易くすると共に、当該領域で有効成分が高濃度貯留し得るように構成した。【選択図】なし
