A toothbrush with suctioning and cleaning functions according to an embodiment of the present invention includes a toothbrush rod including a head portion and a handle portion, a brush disposed at the head portion, a through-hole portion formed at the head portion to supply cleaning water to an oral cavity or suction in dirty water from the oral cavity, a guide tube disposed within the toothbrush rod and connected to the through-hole portion to deliver the cleaning water to the through-hole portion or deliver the dirty water suctioned in through the through-hole portion to the outside, and an external main body to supply the cleaning water to the guide tube and to receive the dirty water from the guide tube.