Di Padova, Franco E,Gram, Hermann,Hofstetter, Hans,Jeschke, Margit,Rondeau, Jean-Michel,Van Den Berg, Wim
申请号：
ES15156029
公开号：
ES2677245T3
申请日:
2005.08.04
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An IL-17 binding antibody or fragment thereof comprising both heavy chain (VH) and light chain (VL) variable domains for use in the treatment of an inflammatory arthritis, wherein said IL-17 binding antibody or fragment thereof comprises at least one antigen binding site comprising: (a) a VH comprising in sequence the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence SEQ ID NO: 1, said CDR2 having the amino acid sequence SEQ ID NO: 2, and said CDR3 having the amino acid sequence SEQ ID NO: 3, wherein the hypervariable regions are in accordance with the definition of Kabat； or (b) a VH comprising in sequence the hypervariable regions CDR1-x, CDR2-x and CDR3-x, said CDR1-x having the amino acid sequence SEQ ID NO: 11, said CDR2-x having the amino acid sequence SEQ ID NO: 12, and said CDR3-x having the amino acid sequence SEQ ID NO: 13, wherein the hypervariable regions are in accordance with the definition of Chothia； and (c) a VL comprising in sequence the hypervariable regions CDR1 ', CDR2' and CDR3 ', said CDR1' having the amino acid sequence SEQ ID NO: 4, said CDR2 'having the amino acid sequence SEQ ID NO: 5, and said CDR3 'having the amino acid sequence SEQ ID NO: 6 wherein the hypervariable regions are in accordance with Kabat's definition.Un anticuerpo de unión a IL-17 o fragmento del mismo que comprende dominios variables tanto de cadena pesada (VH) como de cadena ligera (VL) para uso en el tratamiento de una artritis inflamatoria, en donde dicho anticuerpo de unión a IL-17 o fragmento del mismo comprende al menos un sitio de unión a antígeno que comprende: (a) un VH que comprende en secuencia las regiones hipervariables CDR1, CDR2 y CDR3, teniendo dicha CDR1 la secuencia de aminoácidos SEQ ID NO: 1, teniendo dicha CDR2 la secuencia de aminoácidos SEQ ID NO: 2, y teniendo dicha CDR3 la secuencia de aminoácidos SEQ ID NO: 3, en donde las regiones hipervariables están de acuerdo con la definición de Kabat； o (b) un VH que compr
