DI PADOVA, FRANCO E.,GRAM, HERMANN,HOFSTETTER, HANS,JESCHKE, MARGIT,RONDEAU, JEAN-MICHEL,VAN DEN BERG, WIM
申请号：
ES10174725
公开号：
ES2536228T3
申请日:
2005.08.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
An IL-17 binding antibody, or one of its fragments, comprising both heavy chain (VH) and light chain (VL) variable domains, for use in the treatment of ankylosing spondylitis, wherein said antibody of IL-17 binding, or one of its fragments, comprises at least one antigen binding site comprising: a) a VH comprising, in sequence, the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence SEQ ID NO: 1, said CDR2 having the amino acid sequence SEQ ID NO: 2, and said CDR3 having the amino acid sequence SEQ ID NO: 3, wherein said hypervariable regions are in accordance with Kabat's definition； or a VH comprising, in sequence, the hypervariable regions CDR1-x, CDR2-x and CDR3-x, said CDR1- x having the amino acid sequence SEQ ID NO: 11, said CDR2-x having the amino acid sequence SEQ ID NO: 12, and said CDR3-x having the amino acid sequence SEQ ID NO: 13, wherein said hypervariable regions are in accordance with the definition of Chothia； and b) a VL comprising, in sequence, the hypervariable regions CDR1 ', CDR2' and CDR3 ', said CDR1' having the amino acid sequence SEQ ID NO: 4, said CDR2 'having the amino acid sequence SEQ ID NO: 5, and said CDR3 'having the amino acid sequence SEQ ID NO: 6.Un anticuerpo de unión a IL-17, o uno de sus fragmentos, que comprende ambos dominios variables de cadena pesada (VH) y cadena ligera (VL), para su uso en el tratamiento de la espondilitis anquilosante, en el que dicho anticuerpo de unión a IL-17, o uno de sus fragmentos, comprende al menos un sitio de unión al antígeno que comprende: a) un VH que comprende, en secuencia, las regiones hipervariables CDR1, CDR2 y CDR3, teniendo dicha CDR1 la secuencia de aminoácidos SEQ ID NO:1, teniendo dicha CDR2 la secuencia de aminoácidos SEQ ID NO:2, y teniendo dicha CDR3 la secuencia de aminoácidos SEQ ID NO:3, en el que dichas regiones hipervariables están de acuerdo con la definición de Kabat； o un VH que comprende, en secuencia, las regiones hipervariables CDR1-x,
