УЭСТ Джеймс Уилльям (US),СЭЙДЖЕРТ Джейсон Гэри (US),БЕССЕТТ Пол Х. (US),ЛОУМАН Генри Бернард (US),СТАГЛИАНО Нэнси Э. (US),ВАСИЛЬЕВА Ольга (US),МЕНЕНДЕС Элизабет-Эдна Мэри (US)
申请号：
RU2015101803
公开号：
RU2015101803A
申请日:
2013.06.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An isolated fully human monoclonal antibody that binds Jagged 1 and Jagged 2.2. The antibody of claim 1, which comprises a VH CDR1 sequence comprising the amino acid sequence of SYAMS (SEQ ID NO: 200)； the VH CDR2 sequence containing the amino acid sequence SIDPEGRQTYYADSVKG (SEQ ID NO: 208)； the VH CDR3 sequence containing the amino acid sequence DIGGRSAFDY (SEQ ID NO: 209)； the CDR1 VL sequence containing the amino acid sequence RASQSISSY (SEQ ID NO: 210)； the VL CDR2 sequence containing the amino acid sequence AASSLQS (SEQ ID NO: 211)； and a CDR3 VL sequence containing the amino acid sequence QQTVVAPPL (SEQ ID NO: 212). 3. The antibody of claim 1, which comprises a combination of the CDR1 VH sequence, the CDR2 VH sequence, the CDR3 VH sequence, the CDR1 VL sequence, the CDR2 VL sequence, and the CDR3 VL sequence selected from the combinations shown in Table 2.4. The antibody according to claim 3, which contains a combination of the variable region of the heavy chain and the variable region of the light chain from the combinations listed in table 4.5. The antibody of claim 1, which binds Jagged 1 and Jagged 2 and prevents the binding of one or more Jagged 1 or Jagged 2 to the Notch receptor. The antibody of claim 1, which is an IgG isotype antibody. The antibody of claim 6, which is an IgG1 isotype antibody. An antibody according to claim 1, comprising an agent conjugated to an antibody. The antibody of claim 8, wherein the agent is a therapeutic agent, an antineoplastic agent, a toxin or fragment thereof, a detectable residue, or a diagnostic agent. The antibody of claim 8, wherein the agent is conjugated to the antibody via a linker. The antibody of claim 10, wherein the linker is a cleavable linker. A pharmaceutical composition comprising an antibody according to any one of the preceding claims and a carrier.1. Выделенное полностью человеческое моноклональное антитело, которое связывает Jagged 1 и Jagged 2.2. Антитело по п. 1, которое содержит последовательн
