An anti-Vasohibin-2 antibody, a genetically recombinant anti-Vasohibin-2 antibody, or a fragment thereof, which recognizes amino acid numbers 269 to 288 of the amino acid sequence shown in SEQ ID NO: 2. The anti-Vasohibin-2 antibody of the present invention recognizes a Vasohibin-2 protein with an excellent specificity, and can inhibits an action of promoting angiogenesis owned by the Vasohibin-2 protein, so that the pharmaceutical composition containing the anti-Vasohibin-2 antibody is suitably used in the treatment of a disease requiring inhibition of angiogenesis such as cancer, and the like.
