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INHIBITEUR DU CANAL CALCIQUE DE TYPE T DÉPENDANT DE LA TENSION
专利权人:
Kinki University;Nippon Chemiphar Co., Ltd.
发明人:
申请号:
EP18741980.9
公开号:
EP3572403A1
申请日:
2018.01.22
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
A compound represented by General Formula (I), a tautomer, a stereoisomer, or a pharmaceutically acceptable salt of the compound, or a solvate thereof is used as a voltage-dependent T-type calcium channel inhibitor,in the formula,A represents a benzene ring which may have a substituent or the like;B represents a hetero-fused ring consisting of a 5- or 6-membered heteroaryl ring having one to three same or different heteroatoms selected from an oxygen atom, a sulfur atom, and a nitrogen atom, and a carbon atom, as a ring-constituting atom, and a benzene ring, or the like, and the hetero-fused ring may have a substituent, and is bonded to a cyclopropyl group via a carbon atom constituting these rings;R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like;R2 and R3 may be the same as or different from each other, and each represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like, or R2 and R3 together form CH2CH2 or the like;R4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like;m represents 0, 1, or 2; andn represents 0 or 1.
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