The present invention is directed to Benzomorphan Analog compounds of the Formula I”, Formula IA”, Formula IB”, Formula IC”, or Formula ID” as shown below； and related Formula I’, Formula IA’, Formula IB’, Formula IC’, or Formula ID’； Formula I, Formula IA, Formula IB, Formula IC, or Formula ID； wherein R1, R2a, R2b, R3 and R4 are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.本發明係關於如下所示的式I”、式IA”、式IB”、式IC”、或式ID”之苯並嗎啡烷類似物化合物；及相關之式I’、式IA’、式IB’、式IC’、或式ID’；式I、式IA、式IB、式IC、或式ID；其中R1、R2a、R2b、R3及R4為如同本案中所定義者。本發明化合物可用於治療疼痛、便秘、及其他受類鴉片及ORL-1受體之活性調節之病況。
