the present invention provides a compound of formula I as shown below ", formula IA", the formula IB ", formula IC" benzomorphan analog compound or formula ID " and the related formula I , formula IA, formula IB , formula IC, or formula ID formula I, formula IA, formula IB, formula IC or formula ID (in the formula,, R 1 , R 2a , R 2b , R 3 and R 4 is, of the a is) as defined herein to the subject. the present invention compounds are useful for treating pain, other conditions that are modulated by the activity of constipation as well as opioid and ORL-1 receptor.本発明は、以下に示す式I”、式IA”、式IB”、式IC”または式ID”のベンゾモルファン類似体化合物;および関連する式I’、式IA’、式IB’、式IC’、または式ID’;式I、式IA、式IB、式IC、または式ID(式中、R1、R2a、R2b、R3およびR4は、本明細書で定義された通りである)を対象とする。本発明の化合物は、疼痛、便秘ならびにオピオイドおよびORL-1受容体の活性により調節される他の状態を治療するために有用である。
