Benzomorphan analogs and the use thereof

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专利权人:

Purdue Pharma L.P.

发明人:

Jeffrey Lockman,Laykea Tafesse,Jiangchao Yao,Jianming Yu

申请号：

US14075176

公开号：

US10138207B2

申请日:

2013.11.08

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention is directed to Benzomorphan Analog compounds of the Formula I″, Formula IA″, Formula IB″, Formula IC″, or Formula ID″ as shown below； and related Formula I′, Formula IA′, Formula IB′, Formula IC′, or Formula ID′； Formula I, Formula IA, Formula IB, Formula IC, or Formula ID； wherein R1, R2a, R2b, R3 and R4 are as defined herein.Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

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