HETEROCYCLE FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING ACTIVITY AND USE THEREOF

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专利权人:

发明人:

TONOGAKI, KEISUKE,殿垣圭介,殿垣圭介,INO, AKIRA,井埜章,井埜章,KOJIMA, EIICHI,儿嶋荣一,兒嶋榮一,KATOU, MANABU,加藤学,加藤學,IWATSU, MASAFUMI,岩津理史,岩津理史,TANAKA, NOBUYUKI,田中伸幸,田中伸幸,FUJIOKA, MASAHIKO,藤冈正彦,藤岡正彥

申请号：

TW100132511

公开号：

TWI567072B

申请日:

2011.09.09

申请国别(地区):

TW

年份:

2017

代理人:

摘要：

The present invention provides a compound useful as AMPK activating agent. Namely, the present invention provides a compound of the following formula, its pharmaceuticallly acceptable salts, or solvates thereof.(wherein,is:R1 each is independently halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, etc. m is an integer of 0~3 R2 is hydrogen or substituted or unsubstituted alkyl X is -O- Y is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl).本發明提供在做為AMPK活化劑上有用之化合物,係為下式所示之化合物、其製藥上容許之鹽或此等之溶劑合物,該式如下:(式中,所示之部分為:R1各自獨立為鹵素、羥基、氰基、硝基、羧基、經取代或未經取代之烷基、經取代或未經取代之烯基等;m為0~3之整數;R2為氫或者經取代或未經取代之烷基;X為-O-;Y為經取代或未經取代之芳基或者經取代或未經取代之雜芳基)。

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