The present invention relates to non-solvate crystals A, B and C of N- (2-aminophenyl) -6- (7-methoxyquinolin-4-yloxy) -1-naphthamide and a method for producing the same. The present invention further includes a pharmaceutical composition comprising the crystal, and an application of the crystal in the preparation of a medicament for treating a disease associated with abnormal protein kinase activity or abnormal histone deacetylase activity. [Selection] Figure 1本発明は、Ｎ－（２－アミノフェニル）－６－（７－メトキシキノリン－４－イルオキシ）－１－ナフトアミドの非溶媒和物結晶Ａ、Ｂ、Ｃ及びその製造方法に関する。本発明は、さらに、前記結晶を含む医薬組成物、及び前記結晶の、プロテインキナーゼ活性異常、又はヒストン脱アセチル化酵素活性異常に関連する疾患を治療するための医薬品の調製における応用。【選択図】図１
