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NEW DERIVATIVE OF 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE
专利权人:
TAIHO PHARMACEUTICAL CO.;LTD.
发明人:
SUGIMOTO Tetsuya (JP),СУГИМОТО Тецуя (JP),SAKAMOTO Toshihiro (JP),САКАМОТО Тосихиро (JP),YAMAMOTO Fuyuki (JP),ЯМАМОТО Фуюки (JP),KOBAYAKAWA Yu (JP),КОБАЯКАВА Ю (JP),EGASHIRA Naoki (JP),ЕГАСИРА Наоки (
申请号:
RU2018144542
公开号:
RU0002713181C1
申请日:
2017.05.19
申请国别(地区):
RU
年份:
2020
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a new compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I)R1 is 4-6-membered monocyclic unsaturated heterocyclic group containing 1 to 3 heteroatoms selected from N, S and O, which can contain 1–3 substituents selected from halogen atoms, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group and C3-C10 cycloalkyl group; R2 represents a hydrogen atom or a halogen atom; R3, R4 and R5, which can be identical or different, each represents a hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group or C3-C6 cycloalkyl group; or R3 and R4, together with the nitrogen atom to which they are bonded, form 4–6 membered monocyclic saturated heterocycle containing 1–3 heteroatoms selected from N, S and O, and R5 represents a hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group or C3-C6 cycloalkyl group; or R4 and R5, together with the nitrogen atom to which they are bonded and a carbon atom adjacent thereto, form 4–6 membered monocyclic saturated heterocycle containing 1 to 3 heteroatoms selected from N, S and O, and R3 represents a hydrogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group or a C3-C6 cycloalkyl group; R6 represents a hydrogen atom; R7 is a C1-C6 alkyl group; R8 represents a hydrogen atom or a C1-C6 alkyl group; X1 is N or CR9, and R9 is a hydrogen atom or a halogen atom; X2 is N or CH; and X3 is N or CH, when the dashed line () denotes a single bond, or C, when the dashed line denotes a double bond, provided that at least one of X1 or X2 is N.EFFECT: compounds have the properties of an Akt kinase inhibitor, Rsk kinase or S6K kinase and can be used as an antitumour agent.9 cl, 7 tbl, 44 exИзобретение относится к новому соединению формулы (I) или его фармацевтически приемлемой соли. Соединения обладают свойствами ингибитора Akt киназы, Rsk киназы или S6K киназы и могут быть использованы в качестве противоопухолевого средства. В формуле (I)R1 представляет собой 4-6-членную м
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