METHOD FOR THE PRODUCTION OF HYDROGEL COMPRISING CHITOSAN AND NEGATIVELY CHARGED POLYELECTROLYTES, AND CELLULAR, POROUS MATERIAL RESULTING FROM SAID HYDROGEL
UNIVERSITE LILLE 2 DROIT ET SANTE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;UNIVERSITE DE LILLE 1, SCIENCES ET TECHNOLOGIES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;CENTRE HOSPITAL
发明人:
Nicolas BLANCHEMAIN,Bernard MARTEL,Claudia FLORES,Frédéric CAZAUX,Feng CHAI,Nicolas TABARY,Marco LOPEZ HEREDIA
申请号：
US15740414
公开号：
US20180186939A1
申请日:
2016.07.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention concerns a method for producing a hydrogel comprising the following steps in succession:a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) comprising amine functions (—NH2)；a second step (ii) consisting in dry mixing at least the powders (A) and (B) from the first step in order to form a mixture of powders；a third step (iii) of suspending the mixture of powders obtained from the second step in an aqueous medium having a pH that can enable the anionic polymer (A) to be dissolved without dissolving the chitosan (B)；a fourth step (iv) of adding an acid to the suspension obtained from the third step in order to form the hydrogel； orthe third (iii) and fourth (iv) steps are replaced by a mixing fifth step (v), comprising mixing an acidified aqueous medium including at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose, and/or at least one phosphate of said compound (C), with said mixture comprising at least the powders (A) and (B) obtained from the second step (ii).
