Method for synthesizing n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide and the mesylate monohydrate salt thereof
ANDREAS LENDER,ALFONS GRUNENBERG,BIRGIT KEIL,JOACHIM REHSE
申请号：
IL23015213
公开号：
IL230152A
申请日:
2013.12.24
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention relates to the crystalline mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide in a definite particle size distribution and a specific surface area range, which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions, as well as to pharmaceutical compositions containing said N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having the afore-mentioned particle size distribution and specific surface area range.
