PROBLEM TO BE SOLVED: To provide a novel pyridazinone compound having an activity of inhibiting P2X7 receptor that is a kind of purine receptor, which is useful in preventing, treating or ameliorating diseases relating to inflammation or immunity.SOLUTION: Disclosed are a novel pyridazinone compound represented by a formula (I), a tautomer of the compound, a prodrug, a pharmaceutically acceptable salt, or a solvate of these compounds.COPYRIGHT: (C)2012,JPO&INPIT【課題】プリン受容体の一種であるP2X7受容体の阻害活性を有し、炎症や免疫などが関わる疾患の予防、治療又は改善に有用な新規ピリダジノン化合物を提供する。【解決手段】式(I)(式中のR1、R2、Q、X、Y及びZは、本文中において定義される。)で表される新規ピリダジノン化合物、該化合物の互変異性体、プロドラッグ若しくはその医薬的に許容され得る塩又はそれらの溶媒和物。【選択図】なし
