GLYCINE, MITOCHONDRIAL ONE-CARBON METABOLISM, AND CANCER

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专利权人:

THE GENERAL HOSPITAL CORPORATION

发明人:

JAIN, MOHIT,NILSSON, ROLAND,MOOTHA, VAMSI K.

申请号：

CA2904350

公开号：

CA2904350A1

申请日:

2014.03.12

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Methods of treatment, diagnosis, and determining prognosis of subjects with cancer, generally comprising determining levels of glycine metabolism or a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2, MTHFD1L, or MTHFD2, and optionally administering an antifolate or an agent that inhibits a mitochondrial 1-carbon (1-C) pathway enzyme, e.g., SHMT2 or MTHFD2.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/