Thomas Menzel;X. Michael Liu;Susan E. Burke;Karl Cummins;David J. Heiler;Abbie Brongo
发明人:
X. Michael Liu,David J. Heiler,Thomas Menzel,Abbie Brongo,Susan E. Burke,Karl Cummins
申请号：
US13564161
公开号：
US08530641B2
申请日:
2012.08.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
