Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8and R9are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.本發明係揭示具有抗細菌活性之化合物。該化合物具有下列結構(I):包括其立體異構物、藥學上可接受之鹽及前體藥物,其中Q1,Q2,Q3,R8及R9均如本文定義。亦揭示與此種化合物之製備及用途有關聯之方法,以及包含此種化合物之醫藥組合物。