PROCÉDÉ POUR LA PRÉPARATION D'ALFOSCÉRATE DE CHOLINE, UTILISABLE EN TANT QUE MATIÈRE PREMIÈRE ALIMENTAIRE, À PARTIR DE PHOSPHATIDYLCHOLINE OU DE LÉCITHINE
KIM, Byung Hee,김병희,KIM, Jeong Eun,김정은,LEE, Jung Eun,이정은,SONG, Ye Jin,송예진,LEE, Soo Jeong,이수정,KIM, Do Hee,김도희
申请号：
KRKR2018/016779
公开号：
WO2019/132549A1
申请日:
2018.12.27
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a method for preparing choline alfoscerate, usable as a food raw material, from phosphatidylcholine or lecithin, and a choline alfoscerate preparation method according to the present invention uses a specific reaction medium and a specific catalytic enzyme, thereby enabling a high purity choline alfoscerate to be effectively prepared. Particularly, the preparation method allows a mixed solvent of water and hexane, which have high substrate solubility and an extraction solvent usable in the preparation of food raw materials, to be used as a reaction medium, and enables high purity purification of choline alfoscerate by only using a layer separation process of the reaction medium, thereby enhancing the productivity of choline alfoscerate to be greater than that of a conventional enzymatic synthesis method, having, unlike a conventional chemical synthesis method and a conventional purification method, very simple purification, and enabling the preparation of choline alfoscerate which is usable as a food raw material. Specifically, lecithin is a raw material of fractionated lecithin used as a substrate in the preparation method and is an inexpensive raw material obtained as a by-product in a soybean oil refining process and the like, and thus is expected to be greatly helpful in the commercialization of the preparation method in the future. In addition, choline alfoscerate prepared by the method according to the present invention can be effectively usable as a material for foods, pharmaceuticals and the like for improving cognitive function in patients having had a stroke and having dementia such as Alzheimer's disease.La présente invention concerne un procédé pour la préparation d'alfoscérate de choline, utilisable en tant que matière première alimentaire, à partir de phosphatidylcholine ou de lécithine, et un procédé de préparation d'alfoscérate de choline selon la présente invention utilise un milieu réactionnel spécifique et une enzy
