ITO, KAZUHIRO,STRONG, PETER,RAPEPORT, WILLIAM GARTH,MURRAY, PETER JOHN,KING-UNDERWOOD, JOHN,WILLIAMS, JONATHAN GARETH,ONIONS, STUART THOMAS,HIRST, SIMON CHRISTOPHER,TADDEI, DAVID MICHEL ADRIEN,CHARRON
申请号：
ES09785724
公开号：
ES2461496T3
申请日:
2009.10.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) ** Formula ** in which R 1 is C 1-6 alkyl optionally substituted by a hydroxyl group； R2 is H or C1-6 alkyl optionally substituted by a hydroxyl group； R3 is H； Ar is a naphthyl or a phenyl ring any of which may be optionally substituted by one or more groups independently selected from: C1-6 alkyl, C1-6 alkoxy, amino and mono or di-C1-4 alkylamino； L represents -O (CH2) m- in which m is 0, 1 or 2； Q is selected from: a) a branched or unbranched, unsaturated C1-10 alkyl chain, in which at least one carbon (for example 1, 2 or 3 carbons) is replaced by a heteroatom selected from O, N and S (O) p, wherein said chain is optionally substituted by one or more groups selected from oxo, halogen, an aryl group, a heteroaryl group and a heterocyclyl group, each aryl, heteroaryl or heterocyclyl group that supports 0 to 3 substituents selected from: halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, amino and mono or di-C1-4 alkylamino, with the proviso that the atom directly attached to the carbonyl at -NR3C (O) - no it is an oxygen atom or one of sulfur and b) a (C0-8 alkyl) C5-6 heterocycle, said heterocyclyl group comprising at least one heteroatom selected from O, N and S and is optionally substituted by one or two or three selected groups independently of: halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, amino and m ono or di-C 1-4 alkylamino and p is 0, 1 or 2； or a pharmaceutically acceptable salt or solvate thereof, including all stereoisomers and tautomers thereof.Un compuesto de fórmula (I)**Fórmula** en la que R1 es alquilo C1-6 opcionalmente sustituido por un grupo hidroxilo； R2 es H o alquilo C1-6 opcionalmente sustituido por un grupo hidroxilo； R3 es H； Ar es un naftilo o un anillo fenílico cualquiera de los cuales puede ser opcionalmente sustituido por uno o más grupos seleccionados independientemente de: alquilo C1-6, alcoxi C1-6, amino y mono o di-alquilamino C1-4； L representa -O(CH2)m- en la que m es 0, 1 ó 2； Q se selecciona de: a
