PROBLEM TO BE SOLVED: To provide a composition for use in the treatment of skin conditions such as acne. A composition containing (a) a first component containing a substituted or unsubstituted diindolylmethane compound and (b) a second component containing a substituted or unsubstituted retinoid compound. The composition further comprises a substituted or unsubstituted retinoid compound, an antibiotic compound, a substituted or unsubstituted azelaic acid compound, an oral contraceptive compound, sulfur, a sulfur-containing compound, a substituted or unsubstituted salicylic acid compound, a substituted or unsubstituted Of resorcinol compounds, botanical products, minerals, vitamins, and additional ingredients selected from one or more of the following: The retinoid compound is selected from substituted or unsubstituted first generation retinoids, substituted or unsubstituted second generation retinoids, and substituted or unsubstituted third generation retinoids. [Selection diagram] None【課題】にきびなどの皮膚症状の治療における使用のための組成物の提供。【解決手段】（ａ）置換又は無置換のジインドリルメタン化合物を含む第１の成分と、（ｂ）置換又は無置換のレチノイド化合物を含む第２の成分と、を含有する組成物。組成物が、更なる置換又は無置換のレチノイド化合物、抗生物質化合物、置換又は無置換のアゼライン酸化合物、経口避妊薬化合物、硫黄、硫黄含有化合物、置換又は無置換のサリチル酸化合物、置換又は無置換のレゾルシノール化合物、植物生成物、ミネラル、ビタミン、及び栄養補助製品の１以上から選択される更なる成分を含む組成物。レチノイド化合物が、置換又は無置換の第１世代レチノイド、置換又は無置換の第２世代レチノイド、及び置換又は無置換の第３世代レチノイドから選択される。【選択図】なし
