1. Composition for use in the treatment of skin pathology, a composition comprising: (a) a first component comprising a substituted or unsubstituted compound of diindolylmethane； and (b) a second component comprising a substituted or unsubstituted retinoid compound. 2. The composition of claim 1, wherein the composition comprises an additional component selected from one or more of the following: additional substituted or unsubstituted retinoid compound, antibiotic compound, substituted or unsubstituted azelaic acid compound, contraceptive compound for oral administration, sulfur, sulfur-containing compound substituted or an unsubstituted salicylic acid compound, a substituted or unsubstituted resorcinol compound, a plant product, mineral, vitamin and nutraceutical product Article 3. The composition of claim 1 or 2, wherein the first component comprises a diindolylmethane compound having the following structure: wherein R groups may be the same or different and selected from hydrogen atoms and CC hydrocarbon substituents； and in which indolyl groups are the same or different and may represent indol-3-yl and / or indol-2-yl groups； and in which indolyl groups may be unsubstituted so that all substituents are hydrogen atoms, or may be substituted so that one or more substituents oil selected from C-C.4 hydrocarbon substituents. The composition of claim 3, wherein the first component comprises a substituted or unsubstituted 3,3′-diindolylmethane compound and / or a substituted or unsubstituted 2,2′-diindolylmethane compound selected from the following structures:1. Композиция для применения при лечении кожной патологии, композиция, включающая:(a) первый компонент, включающий замещенное или незамещенное соединение дииндолилметана； и(b) второй компонент, включающий замещенное или незамещенное ретиноидное соединение.2. Композиция по п.1, в котором композиция включает дополнительный компонент, выбранный из одного или более из следующих: дополнительное замещенное или незаме
