POPPLEWELL, Andrew George,KUNZ, Arthur,VIDUNAS, Eugene Joseph,DIJOSEPH, John Francis,SIMPSON, John McLean,ROBBINS, Paul David,MORAN, Justin Keith,RUPPEN, Mark Edward,JAIN, Neera,MERCHANT, Nishith,DAML
申请号：
AU2017204487
公开号：
AU2017204487A1
申请日:
2017.06.30
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017204487A120170720.pdf#####CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES ABSTRACT Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/ antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. (10082632 1):GGG
