Popplewell, Andrew George,Kunz, Arthur,Vidunas, Eugene Joseph,Dijoseph, John Francis,Simpson, John McLean,Robbins, Paul David,Moran, Justin Keith,Ruppen, Mark Edward,Jain, Neera,Merchant, Nishith,Daml
申请号：
AU2012244218
公开号：
AU2012244218A1
申请日:
2012.10.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012244218A120121115.pdf#####CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES A bstract: 5 Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeic calicheamicin derivative/anti-CD22 antibody 10 conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
