Damle, Nitin Krishnaji,Dijoseph, John Francis,Jain, Neera,Kunz, Arthur,Merchant, Nishith,Moran, Justin Keith,Popplewell, Andrew George,Robbins, Paul David,Rubino, Joseph Thomas,Ruppen, Mark Edward,Sim
申请号：
AU2009202609
公开号：
AU2009202609B2
申请日:
2009.06.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2009202609B220120726.pdf#####CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES Abstract: s Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody 10 conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
