САТЬЯЛ Санджив Х. (US),МИТРА Сатьяджит Суджит Кумар (US),ГАРНИ Остин Л. (US)
申请号：
RU2012130364/10
公开号：
RU2012130364A
申请日:
2011.01.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Wnt-binding agent, comprising: (a) a first polypeptide consisting essentially of SEQ ID NO: 39 SEQ ID NO: 32 SEQ ID NO: 33 SEQ ID NO: 34 SEQ ID NO: 35 SEQ ID NO: 36 SEQ ID NO: 37 SEQ ID NO: 38 SEQ ID NO: 40 or SEQ ID NO: 41 and (b) a second polypeptide consisting essentially of SEQ ID NO: 43 or SEQ ID NO: 42 wherein the first polypeptide directly linked to a second polypeptide and etom.2. Wnt-binding agent of claim 1, wherein the first polypeptide consists essentially of SEQ ID NO: 39.3. Wnt-binding agent of claim 1, wherein the first polypeptide consists of SEQ ID NO: 39 and a second polypeptide consists of SEQ ID NO: 43 or SEQ ID NO: 42.4. Wnt-binding agent of claim 1, wherein the first polypeptide consists of SEQ ID NO: 39 and a second polypeptide consists of SEQ ID NO: 43.5. Wnt-binding agent, comprising: (a) a first polypeptide consisting essentially of amino acids Y to X of the sequence SEQ ID NO: 30 and (b) a second polypeptide consisting essentially of the amino acid A to B sequence SEQ ID NO: 43, wherein the first polypeptide directly linked to a second polypeptide and wherein X = amino acid 25, 26, 27, 28, 29, 30 or 31Y = amino acid 156, 157, 158, 159, 160, 161, 162, 163 or 164A = amino acid 1, 2, 3, 4 or 5V = amino acid 231 or 232.6. Wnt-binding agent comprising an amino acid sequence selected from the group consisting of: SEQ ID NO: 53, SEQ ID NO: 50, SEQ ID NO: 48 and SEQ ID NO: 46.7. Wnt-binding agent according to claim 6, characterized in that said amino acid sequence is SEQ ID NO: 53.8. Wnt-binding agent according to claim 6, characterized in that said amino acid sequence is SEQ ID NO: 50.9. A polypeptide comprising a Wnt-binding agent as claimed in any one of claims 1-8, further comprising an amino acid sequence1. Wnt-связывающее средство, содержащее:(a) первый полипептид, состоящий по существу из SEQ ID NO:39 SEQ ID NO:32 SEQ ID NO:33 SEQ ID NO:34 SEQ ID NO:35 SEQ ID NO:36 SEQ ID NO:37 SEQ ID NO:38 SEQ ID NO:40 или SEQ ID NO:41 и(b) второй полип
