MIAO, ZHENWEI,KRAWITZ, DENISE,KRAYNOV, VADIM,TIAN, FENG,SIM, BEE-CHENG,HO, LILLIAN,PUTNAM, ANNA-MARIA, A
申请号：
NZ58482508
公开号：
NZ584825A
申请日:
2008.11.20
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
Disclosed is an insulin polypeptide comprising (i) a modified insulin A-chain amino acid sequence such as GIVEQCCTSICSLYQLENYCN wherein the tyrosine residue at position 14 is thereof is substituted with a non-naturally encoded amino acid (NEAA) and (ii) a water-soluble polymer linked covalently by an oxime bond to said NEAA.
