Габивов Александр (RU),Белогуров Алексей (RU),Пономаренко Наталья (RU),Смирнов Иван (RU),БЕЙКОН Эндрю (GB),ГРЕГОРИАДИС Грегори (GB)
申请号：
RU2014145237
公开号：
RU2014145237A
申请日:
2013.04.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A composition for treating multiple sclerosis, comprising three peptides of myelin basic protein (MBP) linked to a first vector where the first MBP peptide consists of the amino acid sequence of SEQ ID NO: 1, the second MBP peptide consists of the amino acid sequence of SEQ ID NO: 2, and third MBP peptide consists of the amino acid sequence of SEQ ID NO: 3, and the first vector comprises a liposome having a surface which is exposed to the target portion that includes a mannose residue or derivative mannozy.2. Composition according to Claim. 1, characterized in that one or more of the MBP peptides covalently linked to vektorom.3. Composition according to Claim. 1, characterized in that one or more non-covalently linked MBP peptide (s) with vektorom.4. Composition according to claim 1, wherein the targeting moiety enhances: (a) delivering MBP peptide to the immune cell. or (b) receipt of MBP peptide in the immune cell compared to the MBP peptide associated with the vector in the absence of target chasti.5. Composition according to Claim. 1, characterized in that the peptides of MBP encapsulated liposomoy.6. Composition according to Claim. 1, characterized in that the average diameter of liposomes is of 100-200 nm.7. Composition according to Claim. 1, wherein the liposome and the target fragment contains mannozilirovanny lipid.8. A composition according to claim. 7, characterized in that the lipid is mannozilirovannym tetramannozil-3-L-lysine-dioleoyl glitserina.9. A composition according to claim. 7, characterized in that the lipid is mannozilirovannym manDOG.10. Use of a composition according to any one of claims. 1-9 in the manufacture of a medicament for treating multiple sclerosis in a subject in need thereof patsienta.11. Use according to claim. 10, characterized in that the composition has a dosage form for weekly priema.12. Use according to claim. 10, characterized in that to1. Композиция для лечения рассеянного склероза, содержащая три пептида основного бел
