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Stable pharmaceutical solution formulations for pressurized inhalers for the administration of metered doses.
专利权人:
CHIESI FARMACEUTICI SPA
发明人:
申请号:
DE122011100049
公开号:
DE122011100049I1
申请日:
2011.09.20
申请国别(地区):
DE
年份:
2012
代理人:
摘要:
An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.
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