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Stable pharmaceutical solution formulations for pressurized dose inhalers
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
LEWIS, DAVID,GANDERTON, DAVID,MEAKIN, BRIAN,BRAMBILLA, GAETANO,FERRARIS, ALESSANDRA
申请号:
DK10166800
公开号:
DK2223682T3
申请日:
2001.05.18
申请国别(地区):
DK
年份:
2012
代理人:
摘要:
An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.
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