This document describes the heterocycle entity, the pharmaceutical composition comprising the heterocycle entity and the methods for treating relevant to PI3 kinase activity disease and symptom using these chemical entities that adjust PI3 kinase activity.本文描述了調節PI3激酶活性的雜環實體、包含所述雜環實體的藥物組合物、以及使用這些化學實體治療與PI3激酶活性相關的疾病和病狀的方法。