Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.本發明描述對蛋白激酶有活性之化合物,以及使用該等化合物治療與包括B-Raf、c-Raf-1、Fms、Jnk1、Jnk2、Jnk3及Kit激酶及其任何突變體之蛋白激酶之異常活性相關之疾病及病症的方法。