This application describes adjust the chemical entities of PI3 kinase activity, the pharmaceutical composition comprising the chemical entities and the method for treating using these chemical entities relevant to P0 kinase activity disease and symptom.本申請描述了調節PI3激酶活性的化學實體、包含所述化學實體的藥物組合物以及使用這些化學實體來治療與P0激酶活性相關的疾病和病狀的方法。