Device for administering an active principle by the oral mucosal route, comprising: • - an ampoule (1) containing a liquid and closed by a seal (10), • - a syringe body (2) provided with a dispensing orifice for dispensing said liquid to the gingival and buccal mucosa, • - a piston (3), • - a piston rod (4), • - a connector (20) formed in one piece with or fixed to said syringe body (2), said connector (20) being designed to connect in a leaktight manner to said ampoule (1), said connector (20) comprising an internal perforator (23) for perforating said seal (10), said internal perforator (23) forming said dispensing orifice of the syringe body (2) during the dispensing of the liquid, said connector additionally comprising an external protective skirt (21) surrounding said internal perforator (23), and said connector (20) comprising an annular receiving space (24) for receiving said peripheral axial edge (11) of said ampoule (1), said annular receiving space (24) being defined between said internal perforator (23) and said external protective skirt (21).Dispositif dadministration dun principe actif par voie per-muqueuse buccale, comportant: • - une ampoule (1) contenant un liquide obturée par un opercule (10), • - un corps de seringue (2) pourvue dun orifice de distribution pour distribuer ledit liquide sur les muqueuses gingivo-jugales, • - un piston (3), • - une tige de piston (4), • - un connecteur (20) formé dune pièce avec ou fixé audit corps de seringue (2), ledit connecteur (20) étant adapté à se connecter de manière étanche à ladite ampoule (1), ledit connecteur (20) comportant un perforateur interne (23) pour perforer ledit opercule (10), ledit perforateur interne (23) formant ledit orifice de distribution du corps de seringue (2) lors de la distribution du liquide, ledit connecteur comportant en outre une jupe protectrice externe (21) entourant ledit perforateur interne (23), et ledit connecteur (20) comportant un espace de réception annulaire (24) pour re
